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Topic: Parenteral hepatitis viruses В, D, С, G. Laboratory diagnosis of viral hepatitis В, D, С, G

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       Date ____________

Class 12

Topic: Parenteral hepatitis viruses В, D, С, G. Laboratory diagnosis of viral hepatitis В, D, С, G

Questions to be discussed:

1. Taxonomy of parenteral hepatitis viruses (В, D, С, G).

2. Morphology and structure of the hepatitis В virus.

3. Reproductive cycle of HBV.

4. Pathogenesis and clinical symptoms of the hepatitis B.

5. Integrative infection of hepatocytes with HBV.

6. Characteristic features of HDV. Co-and superinfection with HBV.

7. Characteristic features of HCV.

8. Characteristic features of HGV.

9. Characteristic features of hepatitis caused by HCV.  

10.  Laboratory diagnosis of viral hepatitis B, D, С and G.

11.  Specific prophylaxis of viral hepatitis type В and D.

Practical tasks:

1. Examine the main structures of the hepatitis B, and D viruses. Describe the futures of the given virus particles.

 

                                                                           

          

2. Label the stages of the HBV reproductive cycle and mark the main targets for treatment:

 

    ________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

 

12. Examine the main structures of the hepatitis C

 

13. Label the stages of the HCV reproductive cycle and mark the main targets for treatment:

 

14. Complete a scheme of the laboratory diagnosis of the hepatitis В, D, С, G

 

 

Specimen:                                                                                                                  
_____________method    ______________method _______________ method
1. Identification of the viral Ags: ELISA Determination of Abs: ELISA                 Identification of the viral genes: PCR
HBV: HBeAg; HBsAg                                Ig M   Anti – HBc                                          Ig G                             Ig M   Anti – HBe                                       Ig G    Anti – HBs  
  HDV: HDAg              Ig M Anti – HD                             Ig G  
  HCV: HCAg Anti – NS3 – Ag HC  
HGV: HGAg              Ig M Anti – HG                             Ig G  

15. Describe preparations used for treatment and specific prevention of viral parenteral hepatitis (interferon, donor immunoglobulins, vaccines, antiviral drugs):

 

Recombinant HBs- vaccine: ________________________________________________________________________________________________________________________________________ ___________________________________________________________________________________________       

 

Teacher’s signature ________________

 


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