Topic: Immunological aspects of the COVID-19. CP2.

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Date__________________

CLASS 8

Topic: Immunological aspects of the COVID-19. CP2.

Questions to be discussed:

1. The role of APCs in the immune response against SARS-Co-V-2 development.

2. Importance of the humoral and cell-mediated adaptive immune response in COVID.

3. Main cytokines that mediate the cytokine storm development.

4. Immunopathogenesis of COVID-19.

5. Vaccines developed against COVID-19

Practical task:

1. Describe the stages of the immunity development during SARS-Co-V-2 infection.

2. Give example of the current approaches of the immunotherapy of the COVID-19.

IFN-based	Ab-based	Cytokine storm management

CP 2

I. Practical task:

- choose a diagnostic test to identify the type of the hypersensitivity reaction (type 1-4);

- indicate the way of prevention of the hypersensitivity reaction (type 1-4);

II. Oral answer.

Control questions for oral answer

1. Characteristic features of anti-bacterial immunity.

2. Characteristic features of antiviral immunity.

3. Characteristic features of fungi as causative agents of infections. Anti-fungal immunity mechanisms.

4. Characteristic features of protozoan pathogens and anti-protozoa immunity.

5. Characteristic features of helminthes. Anti-helminthes immunity. `

6. Microbial evasion of innate and acquired immunity.

7. Methods of immune response estimation.

8. Allergens. Classification. Microbial and non-microbial allergens.

9. Hypersensitivity reactions Type I (immediate type). Mechanisms of development. Anaphylaxis. Atopy. Diagnostic tests. Desensibilization.

10. Hypersensitivity reactions Type II. Complement- and antibody-depended cytotoxicity. Mechanisms of development. Clinical examples.

11. Hypersensitivity reactions Type III (immune complex reactions). Mechanisms of development. Serum sickness and its prophylaxis.

12. Hypersensitivity reactions Type IV (delayed type). Mechanisms of development. Contact allergy. Hypersensitivity in infectious diseases. Microbe allergens. Methods of sensibilization detection: skin tests and laboratory tests (lymphocyte blast transformation reaction, leukocyte migration inhibition reaction etc).

13. Immunodefficiencies. Classification. Examples.

14. Autoimmune diseases. Examples. Methods of diagnosis.

15. Immunomodulators. Classification. Examples.

16. The role of APCs in the immune response against SARS-Co-V-2 development.

17. Importance of the humoral and cell-mediated adaptive immune response in COVID.

18. Main cytokines that mediate the cytokine storm development.

19. Immunopathogenesis of COVID-19.

20. Vaccines developed against COVID-19

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