Topic: Rhabdoviruses. Laboratory diagnosis of rabies. Arboviruses. Laboratory diagnosis of toga-, flavi-, and bunyavirus infections.

Date ____________

Class 11

Topic: Rhabdoviruses. Laboratory diagnosis of rabies. Arboviruses. Laboratory diagnosis of toga-, flavi-, and bunyavirus infections.

Questions to be discussed:

Classification of the Family Rhabdoviridae.
Morphology and structure of the rabies virus.
Reproduction of the rabies virus.
Pathogenesis and clinical symptoms of rabies.
Laboratory diagnosis of the rabies.
General and specific prophylaxis of rabies. Epidemiological characteristics of arboviruses: natural hosts and vectors.
Main members of arboviruses from the families Togaviridae, Flaviviridae, Bunyaviridae.
Morphology, structure, and replication of the togaviruses.
Rubella virus as a cause of human infections. Morphology and structure.
Pathogenesis of rubella infectioon.
Morphology, structure, and replication of the flaviviruses..
Morphology, structure, and replication of the bunyaviruses.
Main clinical features of arboviruses’ infections: fever, haemoragic fever, encephalitis, and meningoencephalitis.
Pathogenesis and clinical symptoms of tick-born encephalitis.
Basic principles of the diagnosis of arboviral infections.
General and specific prophylaxis of arboviral infections.

Questions to be discussed:

1. Label the main structures of the rabies virus:

2. Complete a scheme of the rabies virus replication and label the main stages:

3. Label the Babes-Negris’ inclusion bodies’ seen under the light microscope in image-smears of the brain tissues:

4. Complete a scheme of the laboratory diagnosis of rabies:

Specimen:
IF	____________________method	_________________method
1. Identification of the viral Ag	Cytoplasmic Babes-Negri inclusion bodies detection	Sucking mice intracerebral in vivo inoculation Nt test in vivo

5. Describe anti-rabies immunobiological preparations used for treatment and prophylaxis:

Anti-rabies immunoglobulin: ________________________________________

______________________________________________________________________

Rabies vaccines: _________________________________________________

______________________________________________________________________

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6. Compare the structure of the virions from different taxonomic groups, that are classified as arbovituses, and give brief descriptions of each group structure..

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