5. Study the effector functions of the immunoglobulins

Date__________________

CLASS 3

Topic: Cell involved in humoral immune response development.. Antibodies, structure and function. Monoclonal antibodies. Cells cooperation in cellular immune response development. Anti-tumor immunity.

Questions to be discussed:

1. Cells involved in the immune response development (APCs, T cells, B cells). Cellular (receptor) and mediator (cytokines) cooperation in humoral immune response.

2. Primary and secondary immune responses. Immunological memory.

3. T-dependent and T-independent immune responses.

4. Immunoglobulin (Ig): structure, classes of Ig, properties.

5. Effector functions of the antibodies.

6. Genetic regulation of the antibody production.

7. Monoclonal antibodies, production, application in treatment and diagnosis.

8. Cells involved in generation of cell-mediated immune responses: main surface receptors, function, lymphokines and monokines.

8. Receptor and mediator cell-cooperation in cell-mediated immune response.

9. Effector function of T cytotoxic lymphocytes.

10. Effector function of Th1 DH lymphocytes.

11. Classification of tumor antigens basing on the pattern of expression (tumor specific Ag and tumor associated Ag).

12. General features of anti-tumor immunity.

Practical tasks:

Describe functions of the molecules, participating in cell cooperation in immunological synapse formation:

Draw a scheme of receptor and mediator cells cooperation in humoral immune response.

T-dependent T-independent

3. Draw a scheme of the human immunoglobulin G basic structure. Label the components of the antibody molecule.

4. Complete a scheme of monoclonal antibodies production.

5. Study the effector functions of the immunoglobulins

Draw a scheme of receptor and mediator cells cooperation in cell-mediated immune response.

7. Describe the target cell recognition and their killing by T CTL cell.

8. Describe the main mechanisms of the anti-tumor immunity.

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