generation (3), 2 generation (1), 3 generation (3).

1 generation (3), 2 generation (1), 3 generation (3).

9. Identify kanamycin, gentamicin, amikacin

Spectrum	А	B	C
Cocci	+	+	+
E. coli, Shigella, Salmonella	+	+	+
Pathogens of plague, tularemia, brucellosis	+	+	+
Mycobacteria	-	+	+
Pseudomonas aeruginosa	+	-	+
Flora resistant to drugs A and B			+

10. What are the indications for use:

a) doxycycline, b) chloramphenicol, c) amikacin:

Intestinal infections; neuroinfections; urinary tract infections; bile duct infection; Pseudomonas aeruginosa infection.

11. Complete the statements:

Chloramphenicol is an antibiotic of the reserve, because ...

Streptomycin should not be administered together with furosemide, because ...

Neomycin is applied topically in combination with glucocorticoids in order to ...

12. Case problem

The dentist discovered a three years old child with of multiple caries, a delay in the development of teeth, their deformation, yellowing. What antibiotic did the mother take during pregnancy?

13. Identify tetracycline, chloramphenicol, streptomycin:

Complication	А	B	C
Syndrome of irritation of mucosa	+	+	-
Hepatotoxic effect	+	+	-
Ototoxic effect	-	-	+
Nephrotoxicity	-	-	+
Inhibition of hematopoiesis	±	+	-
Violation of neuromuscular conduction	-	-	+
Defect in the rudiment of teeth and bones	+	-	-

14. Choose the correct answer:

Polymyxin M in the microbial cell disrupts (protein synthesis / permeability of the cytoplasmic membrane), acts (bacteriostatic / bactericidal) on (Gr + / Gr-flora), the resistance of microorganisms develops (fast / slow)

15. Classify anti-tuberculosis drugs:

streptomycin, kanamycin, isoniazid, rifampicin, ethambutol, pyrazinamide, aminosalicylic acid - on antibiotics and synthetic drugs.

16. Answer the questions:

Isoniazid and rifampicin are class A antituberculosis drugs, because...

In the treatment of patients with tuberculosis, several drugs are prescribed simultaneously, because..

Aminosalicylic acid enhances the action of isoniazid, because ...

It is advisable to administer isoniazid with vitamin B6, because..

17. Identify the drug:

A. The drug from the group of lincosamide, inhibits the synthesis of protein, acts bacteriostatic on anaerobes, cocci. It penetrates well into bone tissue. It is prescribed for infections of the abdominal cavity, ENT organs, with diseases of bones, joints. It is used orally, parenterally, topically. It can cause pseudomembranous colitis.

B. The glycopeptide antibiotic disrupts the synthesis of the cell wall. It acts bactericidal on cocci, including β-lactamase producing, clostridia. It is used intravenously or orally for serious infections. It passes well through the CNS, can be used for meningitis. It is toxic. It can cause neuro-, hemato-, nephrotoxicity.

G. Synthetic antituberculosis drug violates the synthesis of mycolic acids. It is bactericidal. It penetrates well into tissues, cells, caseous foci, through the BBB. It is used inside and parenteral. It can cause polyneuropathy

18.Determine anti-TB drugs ethambutol, isoniazid, kanamycin, rifampicin.

	Spectrum	Mechanism of action	Resistance	Side effects
А	Wide	Block of DNA-dependent RNA polymerase	Fast	Allergic reactions, hepatotoxicity, dysbacteriosis
B	Mycobacteria	Violation of the synthesis of mycolic acids, violation of cellular respiration.	Slow	Peripheral neuritis, convulsions, insomnia.
C	Wide	Violation of protein synthesis, violation of the permeability of the cytoplasmic membrane	Fast	Hearing loss, vestibular disorders, impaired renal function, allergic reactions.
D	Mycobacteria	Disturbance of the synthesis of RNA and proteins	Slow	Visual impairment, allergic reactions

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