Individual work. student of _____ group. Lesson 8 (II). Regulation of protein synthesis. Hereditary diseases.

Individual work

student of _____ group

_______________________________________________

^(name)

Lesson 8 (II). Regulation of protein synthesis. Hereditary diseases.

1. Name the main structural parts of operon, characterize their functions.

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2. What is the function of protein-repressor? What is the mechanism of its realization?

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3. What functional states of repressor protein in inducible operon in:

presence of inductor _______________________________________________________________

absence of inductor _______________________________________________________________

4. What is the CAP-site of inducible operons? What is its function?

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5. Name known types of mutations, characterize changes in DNA and protein structure.

1) _____________________________________________________________________________

2) _____________________________________________________________________________

3) _____________________________________________________________________________

4) _____________________________________________________________________________

5) _____________________________________________________________________________

6) _____________________________________________________________________________

7) _____________________________________________________________________________

6. Explane molecular changes in hemoglobin A that take place in sickle cell anemia.

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7. What are thevreasons of thalassemias? Name known variants of thalassemias.

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8. What positive effect of hemoglobinopathies for human population is possible?

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9. Fill in the table "Inherited enzymopathies".

Disease	Deficient enzyme	General complex of symptoms
Von Gierke's disease
		Accumulation of galactose-1-phosphate in tissues, blood and urine, damage of liver, mental retardation, and cataracts
	glucose-6-phosphate dehydrogenase
Phenyl-ketonuria
	oxidase of homogentisic acid
Tay-Sachs disease