Conclusions.. Exercise 2. The influence of thyroxine, thyroid stimulating hormone (TSH, thyrotropin) and. propyltiouracil on the metabolism of rats. Methodic of this work.. See the effect of thyroxine, thyrotropin and propyltiouracil on the body. Virtual

Conclusions.

1. Compare the effect of alloxan, insulin, insulin+alloxan of blood glucose level in rat.

2. What role of the B - cells of the islets of Langerhans of the pancreas.

Exercise 2

The influence of thyroxine, thyroid stimulating hormone (TSH, thyrotropin) and

propyltiouracil on the metabolism of rats

TRH(thyrotropin-releasing hormone), is hormone that produced by neurons in the hypothalamus. TRH stimulates the release of TSH (thyroid-stimulating hormone) by anterior pituitary. TSH stimulate thyroid gland to production of triiodothyronine (T3) and thyroxine (T4). T3and T4 inhibit the production of TSH from thyroid gland and TRH in the hypothalamus (negative feedback) and the level of T3 and T4 decreases.

Methodic of this work.

The work is carried out in a computer version, demonstration. To get acquainted with the influence of hormones on the exchange. Note that propyltiouracil inhibits the release of thyroxine. To get acquainted with methods of research of metabolism, the device of the respiratory chamber for animals. The breathing chamber is isolated from atmospheric air. When breathing, the animal absorbs oxygen and releases carbon dioxide, which is absorbed by sodium (sodium) lime. The volume of air in the chamber decreases, which is fixed by means of a water pressure gauge. On a gauge scale, you can determine the amount of oxygen absorbed.

!!! See the effect of thyroxine, thyrotropin and propyltiouracil on the body

(Virtual experiments) VIDEO file and fill the table

(1) To determine oxygen consumption (ml for 1 minute) to healthy animals.

(2) Enter thyroxine. To determine oxygen consumption.

(3) Enter the thyrotropin (TSH). To determine oxygen consumption.

(4) Introduce propyltiouracil. To determine oxygen consumption.

	(1)Control (Intact Rat)	(2) Thyroxin	(3) TSH	(4) propyltiouracil
O₂ ml

Conclusions.

How are oxygen uptake and energy metabolism related?

Compare the obtained values of oxygen consumption.

To conclude about the role of thyroxine in the exchange.

To draw a conclusion about the role of thyroid-stimulating hormone (thyrotropin, TSH).

To conclude about the value of the pituitary gland in the regulation of metabolism.

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