Individual work. student of _____ group. Lesson 6. ENZYMES: REGULATION OF ACTIVITIES. ENZYMOPATHIES.

Individual work

student of _____ group

_______________________________________________

^(name)

Lesson 6. ENZYMES: REGULATION OF ACTIVITIES. ENZYMOPATHIES.

1. Give the definitions of the followings terms:

Allosteric site of enzyme molecule – ______________________________________________

_____________________________________________________________________________ Activators of enzymes– ________________________________________________________

_____________________________________________________________________________ Inhibitors of enzymes– ________________________________________________________

_____________________________________________________________________________

2. Name the mechanisms ofenzyme’s activity regulation illustrated by this pictures.

inhibition by product Z

end product

А ___________________________________________________________________________

Hydrolysis

inactive precursor active enzyme

B _________________________________________________________________________

3. How the type of inhibition is named, when inhibitor has structure similar to substrate and binds with active site of enzyme? _______________________________________________________

4. What is the mechanism of regulation of gastrointestinal proteolytic enzymes activity? Why?

_______________________________________________________________________________________________________________________________________________________________________________________________________________________________________

5. Write an example of negative feedback inhibition. _____________________________________

_____________________________________________________________________________

6. Explain, what diseases are called enzymopathies?

__________________________________________________________________________________________________________________________________________________________

7. Write the examples of enzymopathies related with amino acids metabolism.

__________________________________________________________________________________________________________________________________________________________

8. Fill the table using the information about two enzymopathies known for you.

9. What is the mechanism of regulation of protein kinase activity (enzyme which takes part in carrying of hormonal signal inside of the target cell)?

__________________________________________________________________________________________________________________________________________________________

10. Indicate a correct answer: Usual mechanism of intracellular reversible regulation of enzymes activity is:

А. methylation; C. carboxylation;

B. phosphorilation; D. proteolysis.

11. What are isoenzymes? (Give the examples).

12. Choose which of the following isoforms are creatin kinase isoenzymes? (underline correct). How this enzyme can be used in medicine?

ММММ ααγγ МММН ααββ ММНН МВ МННН ММ НННН ВВ ССRR

13. Indicate the isoforms of lactate dehydrogenase concentration of which is maximal in the myocardial cells by red colour, and characteristic to the liver cells – by blue.

LDH1 LDH2 LDH3 LDH4 LDH5

14. Determination of enzymes activity plays a grate role in the diagnostic of myocardial infarction. What enzyme investigation will be the most important after 2–4 hours post infarction?

А. Creatin phosphokinase; C. Lipoproteinlipase;

B. Acetylcholine esterase; D. Alanine aminotransferase;

E. Aldolase.