Treatment: There is no definite cure for this disease, but several options are available. Medical treatment

(NSAIDS) non- steroidal anti-inflammatory drugs such as ibuprofen, voltaren etc. are helpful in reducing severity of dysmenorrhea.

Combined oral contraceptive pills
Three packs of pills taken continuously are helpful in decreasing the number and frequency of the menstrual cycles thus causing atrophy of the endometriotic spots. 63+7, 84+7.

Progesteens (gestogens)
Such as medroxyprogesterone, 17-oxyprogesterone capronatis, noretisterone etc. given continuously will produce pseudo-decidualization in endometriotic lesions, but has the side effects of weight gain and break through bleeding along with the mood swings.

Dienogest – has the strongest antiproliferative activity for endometrium and in case of prolonged use lead to atrophy of endometrioid foci.

Vizan – Dienogest 2 mg in 1 pill – 1 pill a day every day 6-12 months and more.

Janin (and analigists) – combined oral contraceptive pills (30 mcg etinilestradiol+ dienogest 2 mg).

Antigonadotropins (Danazol, Gestrinon)
Danazol. This drug has androgenic effect and is given in the dose 400-800 mg daily for 3-6 months, but it has the side effects of acne, weight gain and hirsutism.

GnRH agonists (Buserelin, Zoladex, Diferelin) and antagonists (Cetrorelix, Ganirelix)
Present as nasal spray, subcutaneous or intramuscular injection. These drugs cause down-regulation of pituitary function which suppresses ovarian steroid production and induce pseudo menopause. Their side effects include hot flushes, atrophic vaginitis and bone pain unless they are given with hormone replacement therapy. Studies found that GnRH agonists given for endometriosis patients undergoing in-vitro fertilization cycles improves significantly their fertility and decreases preclinical abortions.

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